Notable NFL Week 6 Matchups

Primetime & Spotlight Games

Key Matchup: Jalen Hurts & Eagles’ offense vs. Giants’ pass defense
Storyline: The Eagles open as a 7-point road favorite. This is an NFC East grudge match—Giants always raise their intensity vs Philly.
Fantasy Watch: Eagles’ skill players (RBs, WRs) should be safe starts. For Giants, look for upside if defenses are lax.

Line & Context: Green Bay is opening as a 14.5-point favorite at home over Cincinnati.
Key Matchup: Packers’ offense vs Bengals’ weakened defense & uncertainty at QB
Storyline: Bengals are struggling with injuries and have had instability at quarterback.
Fantasy Watch: Aaron Jones / AJ Dillon get favorable ground lanes; WRs in Green Bay’s offense carry upside; Bengals’ receivers are risky but could pop in garbage time.

Line & Context: The Rams are opening as ~7.5-point favorites over Baltimore.
Key Matchup: Rams’ receivers vs Ravens’ secondary, especially if Baltimore is missing key players
Storyline: Ravens are reeling—injuries, inconsistent play, and pressure to respond. The Rams see a chance to assert dominance.
Fantasy Watch: Tight ends could benefit if defenses collapse; Rams’ WRs are in favorable position; Ravens’ backups might offer sneaky value in attachable leagues.

Line & Context: Las Vegas is favored by ~6.5 points.
Key Matchup: Raiders’ offense vs Tennessee’s defensive front
Storyline: Raiders are desperate to rebound from a string of losses; Titans are seeking momentum after their first win.
Fantasy Watch: Josh Jacobs looks like a positive bet; Titans backs may get work if Raiders control time of possession.

Commanders vs. Bears (Monday Night)
- Bears are 4.5-point underdogs.
- If Chicago’s offense catches fire or Washington’s isn’t sharp, this could be tighter than expected.
- Fantasy angle: Bears’ RBs or WRs in favorable matchup might be sneaky starters.
Other potential surprises:
- Divisional games where cohesion and rivalry matter more than records
- Matchups with backup QBs or injury-depleted defenses
- Home underdogs with crowd and pressure advantages

Huge spreads & blowout potential — Packers vs Bengals is one of the most lopsided early lines in 2025.
Injury implications — Teams like Ravens and Bengals with injury problems could show vulnerability.
Mental & momentum swings — A few bad quarters can cascade; teams coming off bad losses could either dig deep or collapse.
Fantasy volatility — WRs and RBs in favorable matchups or weak defenses will be premium plays; avoid ones facing juggernaut defenses or QB instability.